26.10 Homocysteine

26.10.1 Global tests

Type III ANOVA on main and interaction effects, and LM model summaries.

PRL (ng/ml)
Chisq Df Pr(>Chisq)
(Intercept) 117.9823128 1 <0.0001 ***
Homocysteine 2.2161224 1 0.1 ns
Study 0.0338807 1 0.9 ns
GA_samp 122.0902307 1 <0.0001 ***
Homocysteine:Study 0.0959458 1 0.8 ns
hPL (μg/ml)
Chisq Df Pr(>Chisq)
(Intercept) 31.1427141 1 <0.0001 ***
Homocysteine 0.6346316 1 0.4 ns
Study 3.0978882 1 0.08 ns
GA_samp 1551.6084962 1 <0.0001 ***
Homocysteine:Study 0.0725759 1 0.8 ns
GH2 (ng/ml)
Chisq Df Pr(>Chisq)
(Intercept) 239.2035022 1 <0.0001 ***
Homocysteine 1.5409841 1 0.2 ns
Study 0.8917925 1 0.3 ns
GA_samp 785.9602453 1 <0.0001 ***
Homocysteine:Study 1.7161585 1 0.2 ns
Insulin (uU/ml)
model term df1 df2 F.ratio Chisq p.value
1 Homocysteine 1 Inf 0.759 0.759 0.4 ns
3 Study 1 Inf 1.868 1.868 0.2 ns
4 GA_samp 1 Inf 0.138 0.138 0.7 ns
2 Homocysteine:Study 1 Inf 0.001 0.001 1.0 ns
HOMA-IR
model term df1 df2 F.ratio Chisq p.value
1 Homocysteine 1 Inf 0.548 0.548 0.5 ns
3 Study 1 Inf 3.470 3.470 0.06 ns
4 GA_samp 1 Inf 0.210 0.210 0.6 ns
2 Homocysteine:Study 1 Inf 0.000 0.000 1.0 ns
Glucose (mmol/L)
model term df1 df2 F.ratio Chisq p.value
1 Homocysteine 1 Inf 0.136 0.136 0.7 ns
3 Study 1 Inf 4.358 4.358 0.04 *
4 GA_samp 1 Inf 0.348 0.348 0.6 ns
2 Homocysteine:Study 1 Inf 0.290 0.290 0.6 ns

26.10.2 Model summary

Ratio of Geometric means (95% CI)

PRL (ng/ml)
Var Effect P
(Intercept) 15.39 (9.51, 24.91) <0.0001
Homocysteine 0.97 (0.94, 1.00) 0.05
StudySTOP 1.02 (0.89, 1.16) 0.81
GA_samp 1.16 (1.13, 1.20) <0.0001
hPL (μg/ml)
Var Effect P
(Intercept) 2.09 (1.63, 2.68) <0.0001
Homocysteine 0.99 (0.97, 1.00) 0.12
StudySTOP 1.14 (1.06, 1.23) 0.0002
GA_samp 1.34 (1.32, 1.36) <0.0001
GH2 (ng/ml)
Var Effect P
(Intercept) 0.06 (0.04, 0.09) <0.0001
Homocysteine 1.00 (0.97, 1.02) 0.71
StudySTOP 1.03 (0.94, 1.13) 0.52
GA_samp 1.32 (1.29, 1.34) <0.0001
Insulin (uU/ml)
Var Effect P
(Intercept) 17.53 (9.25, 33.20) <0.0001
Homocysteine 0.98 (0.93, 1.03) 0.36
StudySTOP 0.71 (0.60, 0.86) 0.0003
GA_samp 0.99 (0.96, 1.03) 0.71
HOMA-IR
Var Effect P
(Intercept) 4.31 (2.21, 8.39) <0.0001
Homocysteine 0.98 (0.93, 1.03) 0.44
StudySTOP 0.62 (0.51, 0.75) <0.0001
GA_samp 0.99 (0.95, 1.03) 0.64
Glucose (mmol/L)
Var Effect P
(Intercept) 5.63 (4.88, 6.50) <0.0001
Homocysteine 1.00 (0.99, 1.01) 0.67
StudySTOP 0.87 (0.84, 0.90) <0.0001
GA_samp 1.00 (0.99, 1.01) 0.59

26.10.3 Estimated means

Estimated marginal means (or adjusted means) adjusted for GA at sampling.

Results are averaged over the levels of Homocysteine concentration (μM) and may be misleading when interaction term is involved.

PRL (ng/ml)
Study response SE df lower.CL upper.CL
SCOPE 95.14832 7.868709 102.32772 80.75415 112.1082
STOP 96.72139 7.491155 79.16093 82.90351 112.8424
hPL (μg/ml)
Study response SE df lower.CL upper.CL
SCOPE 89.48048 2.644842 186.9890 84.41212 94.85316
STOP 102.27292 2.678403 115.6379 97.10307 107.71801
GH2 (ng/ml)
Study response SE df lower.CL upper.CL
SCOPE 2.271353 0.0759250 408.5979 2.126899 2.425619
STOP 2.342118 0.0640575 213.6254 2.219195 2.471849
Insulin (uU/ml)
Study response SE df asymp.LCL asymp.UCL
SCOPE 14.32849 0.9049166 Inf 12.660262 16.21653
STOP 10.23459 0.4633987 Inf 9.365476 11.18435
HOMA-IR
Study response SE df asymp.LCL asymp.UCL
SCOPE 3.462311 0.2324445 Inf 3.035429 3.949226
STOP 2.138542 0.1012539 Inf 1.949018 2.346496
Glucose (mmol/L)
Study response SE df asymp.LCL asymp.UCL
SCOPE 5.418600 0.0647559 Inf 5.293156 5.547017
STOP 4.712809 0.0395282 Inf 4.635969 4.790924

26.10.4 Comparisons

Effect for every 1 unit increase in Homocysteine concentration (μM).
Hormone Contrast Study Ratio of Geometric means (95% CI) P-value
PRL (ng/ml) Homocysteine5.6 / Homocysteine4.6 SCOPE 0.97 (0.94, 1.00) 0.05
PRL (ng/ml) Homocysteine5.6 / Homocysteine4.6 STOP 0.97 (0.94, 1.00) 0.05
hPL (μg/ml) Homocysteine5.6 / Homocysteine4.6 SCOPE 0.99 (0.97, 1.00) 0.1
hPL (μg/ml) Homocysteine5.6 / Homocysteine4.6 STOP 0.99 (0.97, 1.00) 0.1
GH2 (ng/ml) Homocysteine5.6 / Homocysteine4.6 SCOPE 1.00 (0.97, 1.02) 0.7
GH2 (ng/ml) Homocysteine5.6 / Homocysteine4.6 STOP 1.00 (0.97, 1.02) 0.7
Insulin (uU/ml) Homocysteine5.6 / Homocysteine4.6 SCOPE 0.98 (0.93, 1.03) 0.4
Insulin (uU/ml) Homocysteine5.6 / Homocysteine4.6 STOP 0.98 (0.93, 1.03) 0.4
HOMA-IR Homocysteine5.6 / Homocysteine4.6 SCOPE 0.98 (0.93, 1.03) 0.4
HOMA-IR Homocysteine5.6 / Homocysteine4.6 STOP 0.98 (0.93, 1.03) 0.4
Glucose (mmol/L) Homocysteine5.6 / Homocysteine4.6 SCOPE 1.00 (0.99, 1.01) 0.7
Glucose (mmol/L) Homocysteine5.6 / Homocysteine4.6 STOP 1.00 (0.99, 1.01) 0.7

26.10.5 Diagnostics

Model diagnositcs.

Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)

26.10.6 Plots